Objective: To prove the effectiveness of Interferential therapy (IFC) in trigeminal neuralgia. Methods: This was a prospective analytical study, conducted at Institute of Physical Medicine &Rehabilitation and Rabia Moon Institute of Neuro Sciences over a period of six months. Thirty one patients who were diagnosed with trigeminal neuralgia and were not responding to medicineswere subjected to interferential therapy. Pain was assessed on visual analogue scale before andafter fifteen days of therapy. Result: Out of 31 patients, 20 males and 11 females, with a mean age of 50.1±11 years, 26 (83.7%) improved significantly with application of IFC.Only 5 (16.3%) patients remained unresponsive to IFC Using an unrelated t test on the data (t=0.19, df = 28).The results were found to be significant at P > 0.05 for the one tailed hypothesis. This means that Interferential current is more effective than medication for reducing pain in trigeminal neuralgia.Conclusion: Interferential therapy is an effective, easy to use therapy with minimal side effects in patients suffering from trigeminal neuralgia not responding to conventional treatment.