Objective: To determine the status of supplementary Polio doses given on National Immunization days and the status of routine immunization of all cases of Polio in Sindh. Study Design: Descriptive/ Cross-sectional Setting: All the districts of Sindh. Methodology: All polio cases reported confirmed by virus isolation in all the districts of Sindh were evaluated for the status of routine and supplementary immunization. Results: A total of 245 children with confirmed Polio were analysed. In 2000 35.3% children with P1W received no supplementary doses while none received 7+ doses while in 2009 all effected children received supplementary doses with 83.3% receiving 7+ doses with a similar pattern for P3W cases. Routine immunization of these children showed that in 2000, 48.4% of P1W cases had not received any routine polio doses as compared to 2009 where 50% were not immunized. A similar pattern was also seen with P3W cases with 41.2% and 66.7% in 2000 and 2009 respectively who did not receive any routine doses Conclusion: Routine immunization of polio patients is poor.Strengthening of routine immunization is an important step to achieve polio eradication.