Objective: In benign prostatic hyperplasia and carcinoma prostate not only prostate specific antigen levels are altered but the levels of other chemical parameters like alkaline phosphatase, urea, creatinine and hemoglobin are also changed. Purpose of this study was same. Design: Case-control study. Subjects and Methods: From the study population of 250 subjects 93 were selected, representing the normals, BPH and CaP cases. Prostate specific antigen, alkaline phos-phatase, urea, creatinine and hemoglobin were estimated. Results: Mean PSA concentration was highly significant (P=0.001) when normals were compared with BPH and CaP case. Significant differences in ALP levels were observed in normals versus CaP cases (P<0.01); BPH versus CaP cases (P=0.01). Serum urea and creatinine levels were insignificant in all the groups. Levels of hemoglobin showed highly significant differences (P=0.001) when normal were compared with CaP cases Conclusion: PSA increases in both BPH and CaP but marked changes were seen in CaP cases but as the carcinoma further progresses changes in ALP and Hb do occur, which should be given due consideration during the management of these diseases.