Background: Mortality among intensive care unit (ICU) patients remains high despite advances in critical care medicine. Identifying predictors of mortality assists clinicians in early risk stratification and improves clinical decision-making.Objective: To determine the clinical, demographic, and laboratory predictors associated with mortality among ICU patients.Methods: A retrospective observational study was conducted among 300 adult patients admitted to the ICU of a tertiary care hospital between January and December 2025. Demographic characteristics, clinical findings, laboratory investigations, severity scores, interventions, and outcomes were analyzed. Logistic regression was used to identify independent predictors of mortality.Results: The overall ICU mortality was 28.7%. Advanced age, higher APACHE II score, presence of sepsis, requirement of mechanical ventilation, acute kidney injury, vasopressor use, elevated serum lactate, and prolonged ICU stay were significantly associated with mortality (p<0.05). Multivariate analysis identified APACHE II score, serum lactate level, mechanical ventilation, and septic shock as independent predictors.Conclusion: Disease severity at admission, organ dysfunction, and need for advanced life-support measures are strong predictors of ICU mortality. Early recognition and aggressive management of these factors may improve patient survival.