Objective: To propose that minicholecystectomy is cost effective and is as effective as laparoscopic cholecystectomy. Study Design: Prospective comparative study Settings: Surgical Unit II of Peoples Medical College Nawabshah, and Jinnah Medical Center Nawabshah, a private hospital, from January 2008 to December 2009. Main Outcome measures: Postoperative pain, Length of hospital stay, Cost of treatment, Time until return to work, Complications. Methodology; From January 2008 to December 2009 sixty eight patients were selected for Mini- and Laparoscopic cholecystectomy. 36 patients in MC group and 32 patients in LC group were included in study. By decreasing the incision size to 4-7 cm preserving the rectus muscle and using headlights we have reduced our operative morbidity at no increased risk to the patient. The strength of this report is the inclusion of all cholecystectomy performed in one unit in a period of two years. The median operative time for MC in our study was 64 minutes (range 45-82 minutes) and is almost equal to that of previous reports (40-74 mins).There was no operative mortality. 20 patients were discharged within 24 hours, and 14 patients need to stay for 48 hours, but two patients with complications remained admitted for one week. Median and mean postoperative stay for all patients was 1.5 to 2.4 days respectively. Conclusion Minicholecystectomy should be considered in every case of gall stone disease particularly in developing countries. Minicholecystectomy is a safe, inexpensive day surgery method of cholecystectomy with minimal time off work after surgery.