Background: Laparoscopic Cholecystectomy (LC) is hazardous in difficult cases due to distorted anatomy at callot's triangle by acute or chronic cholecystitis. Laparoscopic subtotal cholecystectomy (LSC) is a feasible option in severe and complicated cholecystitis minimizing the rate of open conversion. Objectives: To assess the feasibility of LSC without cystic duct clipping thus avoiding the potentially hazardous dissection at callot's triangle in difficult cases. Study design: Descriptive observational study. Place and duration: Conducted at Ghulam Mohammad Maher Medical college hospital and Hira Medical center Sukkur during a period of last three years from Jan 2008 to Dec 2010. Patients and methods: This is a prospective study included 33 patients with severe acute or chronic calculus cholecystitis and having dense adhesions at callot's triangle. Laparoscopic subtotal cholecystectomy was done in all 33 patients without cystic duct dissection or ligation /clipping. When dissection at callot's triangle was found difficult and hazardous and cystic duct could not be identified safely, the LSC was performed. The anterior wall of the gall bladder was incised removing all the stones and excision of the anterior wall was done leaving the posterior wall of the gall bladder. The remnant mucosa of the gall bladder was diathermized. Drain was placed in the Hartmann's pouch and sub hepatic space. The results of all these patients and complications are analyzed. Results: out of 33 patients, 21 patients were females and 12 were males, with male to female ratio 1:2.The median age of the patients was 48 years. The median operative time was 90 minutes and median duration of hospital stay was 03 days. The indications for LSC were severe fibrosis with difficult dissection at callot's triangle in 19 patients, inflammatory mass with distorted anatomy at callot's triangle in 12 patients and gangrenous gall bladder in 02 patients. Temporary postoperative bile leak was found in 04 (12.12%) patients which resolved spontaneously after 7-10 days. Three patients required endoscopic retrograde cholangiopancreatography (ERCP) post operatively with extraction of retained bile duct stones and stent insertion for persistent biliary leaks. One patient required laparotomy for biliary peritonitis and subphrenic collection. No mortality was seen in the study. No complications were associated with ablated gall bladder mucosa. Conclusion: LSC without cystic duct clipping or ligation is an alternative to open conversion in difficult cases to avoid hazardous dissection at callot's triangle. Bile leaks are predictable and readily managed.