Objectives: d in Department of Medicine, Isra University, and Department of Medicine, LUMHS, Jamshoro/Hyderabad. The presenting complaints were presence of distention of abdomen, stupor, irritability, altered sleep pattern, coma and hematemesis. After giving immediate treatment adequate historical information, physical examination and specific pertinent laboratory test results were recorded to the specifically designed proforma after obtaining the informed consent. The main variables studied were frequency of hyponatremia, assessment of degrees of hyponatremia and its effects on the complications of cirrhosis of liver. Results: Out of 100 cases, 67(67%) were male and 33(33%) were female. Hyponatremia was present in 35% patients (n=35/100, total 100). Out of these 20% (n=20) were having mild hyponatremia (Na 135-130 mEq/L), 14% (n=14) moderate hyponatremia (Na 130-125 mEq/L) and only 1% (n=1) severe hyponatremia (Na <125 mEq/L). Twenty eight percent (28%) patients were suffering from hepatic encephalopathy, 23% from bleeding esophageal varices and 9% from spontaneous bacterial peritonitis respectively. Primary outcome was: 63 patients improved and were discharged, 27 patients didn't improved and were still being managed, and lastly 10% patients expired while on treatment. Conclusions: Among hepatic encephalopathy and spontaneous bacterial peritonitis, moderate and severe hyponatremia is one of the major risk factor of mortality and morbidity while normal serum sodium and mild hyponatremia had no effect.