Background: Helicobacter pylori (H. pylori) infection remains one of the most common chronic bacterial infections worldwide and is strongly associated with gastritis, peptic ulcer disease, gastric mucosal atrophy, mucosa-associated lymphoid tissue (MALT) lymphoma, and gastric carcinoma. Early diagnosis and eradication therapy significantly reduce gastrointestinal morbidity.Objective: To determine the prevalence of H. pylori infection among patients presenting with upper gastrointestinal disorders and evaluate its association with various endoscopic findings.Methods: A retrospective observational study was conducted among 250 adult patients who underwent upper gastrointestinal endoscopy for dyspeptic symptoms. Demographic details, clinical presentation, endoscopic findings, rapid urease test (RUT), histopathological examination, and biopsy reports were analyzed. The association between H. pylori infection and upper gastrointestinal diseases was assessed using descriptive and inferential statistics.Results: Among 250 patients, H. pylori infection was detected in 146 (58.4%). Gastritis was the most common endoscopic diagnosis (42.8%), followed by duodenal ulcer (18.4%), gastric ulcer (13.2%), erosive gastritis (10.8%), gastroesophageal reflux disease (GERD) (8.8%), and gastric malignancy (6.0%). H. pylori positivity was significantly higher in patients with duodenal ulcer (84.8%) and gastric ulcer (75.8%) compared with other upper gastrointestinal disorders.Conclusion: H. pylori infection is highly prevalent among patients with upper gastrointestinal disorders and shows a strong association with peptic ulcer disease. Early detection and eradication therapy remain essential for preventing ulcer recurrence and gastric malignancy.