Objective: To determine the frequency of hyperlipidemia in hypertensive patients. Study design: Cross sectional study Setting: Outpatient departments (OPDs) of Medicine and Cardiology of Chandka Medical College Hospital, Larkana. Material and Method: Newly diagnosed hypertensive patients of age 15 to 75, of either sex were enrolled. Eligible patients were subjected for lipid profile ((Serum Triglyceride and Cholesterol). Results: A total of 246 patients were enrolled in this study. Male were 158 (64.2%) and female were 88 (35.8%), with male to female ratio 1.8:1. Enrolled participants were age of 16 to 75 years, with the mean age of 45.9±14.3 years. Of 246 patients, 191 (77.6%) had body mass index of >25 with mean BMI of 28.9±4.6. Out of 246 patients, 63 (25.6%) had family history of hyperlipidemia and 95 (38.6%) had family history of hypertension. The frequency of hyperlipidemia in hypertensive patients was 47 (19.1%) with mean serum cholesterol of 197.7±42 and mean serum triglycerides of 160.4±30. Stratified analysis showed that hyperlipidaemia is more common in patients with family history of hyperlipidaemia and was statistically significant (P-<0.001). Conclusions: It was concluded from this study that hyperlipidemia was more common in patients with hypertension.