Objectives: To evaluate the clinical profile, laboratory parameters and outcome of children admitted with dengue infection. Place and duration: National Institute of Child Health, Karachi from 1stAugust 2011 to 31stOctober 2011. Study designed: Case series. Material and method: Patients presenting with fever fulfilling the WHO case definition and seropositive IgM, IgGfor dengue fever by ELISA method were included in the study. Their age ranged from 2 months to 16 years. Detailed history, physical examination, demographic data, laboratory findings and outcome were assessed and recorded in the proforma. Data was analyzed with appropriate statistical tests. P value of < 0.05 was taken as significant. Results: A total of 39 patients with dengue were studied. Male were 24 while female were 15. The mean age of patient was 7.39 +_ sd 4.69 years. The most common features observed were fever (100%), abdominal pain (51.28%), bodyaches (43.58%) and nausea/vomiting (33.3%), followed by headache (28.20%), diarrhea (17.94%) and skin rash (12.82%).(Table-I). The most common physical sign detected was splenomegaly (79.48%) followed by pallor (53.84%) and hepatomegaly (46.15%.). Thromb-ocytopenia was a constant feature but leucopenia was found in only 06 (15.38%) patients. (Table-I). ALT was elevated in (46.55%) patients. Unfortunately 1 patient expired. Conclusion: Dengue is one of the major emerging viral infections. Children less than 08 years were found to be more vulnerable to dengue fever. Fever, abdominal pain and bodyaches were the common presenting symptoms. Splenomegaly was the most common clinical sign noted followed by pallor and hepatomegaly.