Objectives: To determine the reliability of the pipelle device in recovering an adequate and representative endometrial sample using post hysterectomy histology as gold standard for patients with abnormal vaginal bleeding and to review literature in relation to endometrial biopsy. Study Design: Quasi experimental study. Place and Duration: Department of Obstetrics and Gynecology Combined Military Hospital Peshawar, from 15 th April 2006 to 30 th April 2008. Materials and Methods: A total of 62 patients aged more than 40years already planned for hysterectomy for abnormal uterine bleeding pattern were included after informed consent. Sampling technique was non-probability convenience. Results: The adequacy of pipelle specimen was calculated as 92%. Histopathological findings of pipelle endometrial biopsy significantly correlated with histopathological findings of hysterectomy. The sensitivity of pipelle device was 93.4% and specificity was 100% while positive predictive value was 100% and negative predictive value was 20% in this study. Conclusion: Our study confirms the accuracy and reliability of pipelle sampler by comparing to 'the gold standard'. Literature review further recommends it as a safe, accurate and cost effective tool as compared to traditional D & C and newer modalities as outpatient hysteroscopy.