Objective: To assess the clinical out-come of modified radical mastectomy for management of breast cancer and to evaluate its safety and frequency of complications associated with this surgery Design: Prospective observational study was conducted from July 2008 to June 2012 at Liaquat University Hospital Jamshoro and a private hospital Hyderabad city. Methodology: All patients had routine investigations, staging ultrasound, xray and bone scan. The patients who underwent MRM were included in this study. The procedure was carried out by standard technique. Clinical examination, investigations, postoperative complications were recorded on proforma and results were drawn. Results: Total study population was 78 patients with mean age of 44.21 years ± 13.43. Main per-operative complications observed were seroma formation 34.6% and wound infection in 12.8% cases, skin flap necrosis, paresthesia and hematoma in 5.1% cases. Wound dehiscence, edema and muscular paralysis were seen in 3.8, 2.5 and 1.2% study population respectively. Conclusion: Modified radical mastectomy is mainstay of treatment option for breast cancer management. Modified radical mastectomy is reliable and safe modality in hands of well-trained surgical team observing careful approach. Common complication associated with MRM can be avoided by taking prophylactic measures during surgery and convalescence period.