Objective: The objective of this study was to acquire the detailed information of clinico-radiological presentation of the patients, who were diagnosed & treated as a case of POTT'S DISEASE. Methods: This is hospital based retrospective study conducted at department of Neurology Chandka Medical College Larkana from Jan: 2009 to Dec: 2011. The files of patients who were clinically diagnosed as a case of Pott's disease were reviewed and data was collected from the files. Results: There were 28 patients, who were clinically diagnosed as a case of Pott's disease. Out of these patients, males were in predominance with total No: 21(75%) and females were 07(25%), with the ratio of male to female was 3:1. Mean age of patients was years, most of them belonging to district Larkana, Back pain was presenting complain in 15(53.5%). Paraplegia was presenting complication in 04 (17.8%) patients. Site of spine involved was lower lumbar (L4-S1) region involved in 10(35.7%), followed by upper lumbar (L1-L3) involved in 08 (28.5%), thoracic region in 09(32.1%) patients and cervical region in one patient. Conclusion: As tuberculosis is very common in Pakistan, in our study we found that the spine is one of the most frequently involved region in CNS Tuberculosis in our areas. All the patients with Pott's disease were treated with drug therapy (ATT) and 13(46.4%) patients under went surgery due to Neurological complications. Most of the patient with Pott's disease began to improve 03 months after treatment and healed completely after 12 months.