Background: Acute myocardial infarction (AMI) remains one of the leading causes of morbidity and mortality worldwide despite advances in reperfusion therapy and evidence-based pharmacological management. Understanding clinical outcomes and their predictors is essential for improving patient prognosis.Objective: To evaluate the short-term clinical outcomes of patients admitted with acute myocardial infarction and identify factors associated with adverse outcomes.Methods: A retrospective observational study was conducted among 320 consecutive patients diagnosed with AMI and admitted to a tertiary care hospital between January and December 2025. Demographic characteristics, cardiovascular risk factors, laboratory findings, treatment modalities, complications, and in-hospital outcomes were analyzed.Results: The mean age of patients was 60.8 ± 12.4 years, with males accounting for 69.1% of cases. ST-elevation myocardial infarction (STEMI) constituted 65.6% of admissions. Overall in-hospital mortality was 8.8%. Heart failure (18.4%), cardiogenic shock (9.7%), recurrent ischemia (6.6%), and arrhythmias (16.3%) were the most common complications. Independent predictors of poor outcome included advanced age, diabetes mellitus, delayed hospital presentation, reduced left ventricular ejection fraction (LVEF), cardiogenic shock, and elevated cardiac troponin levels.Conclusion: Early diagnosis, prompt reperfusion therapy, and aggressive management of high-risk patients significantly improve outcomes following AMI. Risk stratification based on clinical and laboratory parameters remains essential for optimizing patient care.